PD Dr. med. Marcus Mumme


Backmumme

Specialist in orthopaedic surgery and musculoskeletal traumatology (FMH), Switzerland
Specialist in orthopaedics and trauma surgery, Germany



Focus of treament

  • Arthroscopic knee surgery and orthobiological methods

  • Cartilage injury, osteochondrosis, early osteoarthritis: Autologous chondrocyte transplantation (ACT and nose-to-knee cartilage tissue engineering), osteochondral transplantation, stem cell and biomaterial treatment methods, collagen membrane and PRP, revision surgery

  • Osteoarthritis treatment for joint preservation, including mechanical axis correction

  • Meniscus injury: Preservative meniscus surgery, partial meniscus resection and replacement, meniscus transplant (allograft), revision surgery

  • Cruciate and collateral ligament injuries: All types of ligament reconstruction on the anterior and posterior cruciate ligament including suturing and internal bracing, healing response, cruciate ligament reconstruction (quadriceps tendons, hamstring/semitendinosus tendons, BTB/patellar tendons, allografts), surgical treatment on loosened and partially ruptured cruciate ligaments, collateral ligament injuries, revision surgery

  • Patellar instability and dislocation (MPFL reconstruction and trochleoplasty, patellar correction, axial and rotational correction),

  • Runner’s knee, jumper’s knee, patellar rupture

  • Treatment of bone disease with joint involvement such as bone bruising and chronic bone oedema, necrosis and cysts

Career history

2019
Habilitation and venia docendi in orthopaedics and traumatology at University of Basel

2019 – current
Medical services at Sport Clinic Zurich

2019 – current
Head of sports orthopaedics and knee surgery at University Children’s Hospital Basel (Prof. Dr. Carol Hasler) and senior physician for cartilage regeneration at University Hospital Basel (Prof. Dr. Daniel Rikli) 

2018               
Master of Advanced Studies in Drug Discovery and Clinical Development, University of Geneva

2017 – 2018
Fellowship Institute for Regenerative Medicine and Biotherapy, CHU de Montpellier (Prof. Dr. Christian Jorgensen)

2015 – 2018
Senior physician for orthopaedics at University Children’s Hospital Basel (Prof. Dr. Carol Hasler) as well as orthopaedics and traumatology at University Hospital Basel (Prof. Dr. Marcel Jakob) 

2015
Specialist in orthopaedics and trauma surgery, Germany
Specialist in orthopaedic surgery and musculoskeletal traumatology (FMH), Switzerland

2014
Resident physician for general and trauma surgery at Bad Säckingen Hospital (Dr. Volker Roth)

2013
Resident physician for orthopaedics at Schulthess Clinic Hospital, Zurich (Prof. hc. PD Dr. Matthias Steinwachs)

2009 – 2012
Resident physician at University Hospital Basel

  • Surgical emergency unit (Dr. Karen Delport)

  • Traumatology (Prof. Dr. Marcel Jakob)

  • Paediatric surgery, University Children’s Hospital Basel (Prof. Dr. Johannes Mayr)

  • Institute for surgical research and hospital management (Prof. Dr. Ivan Martin)

  • General and visceral surgery (Prof. Dr. Daniel Oertli)

  • Anaesthesia and surgical intensive treatment (Prof. Dr. Hans Pargger)

2008
Resident physician for orthopaedics and traumatology, Hôpital Fribourgeois Standort Tafers (Switzerland) (Dr. Christoph Marti, Prof. Dr. Roland Jakob)

2008   
Doctorate: Dr. med., magna cum laude (Grade 1.0)

2007   
State examination and licence to practice medicine, Germany
United States Medical Licensing Examination Step 2 CK

2006   
United States Medical Licensing Examination Step 1

2001 – 2007   
Medical Studies at the University of Hamburg, Germany

2000   
High-school graduation to university matriculation grade, Gymnasium Lerchenfeld high school, Hamburg

Awards     

  • Dirk Schäfer research award from the Department of Surgery at University Hospital Basel for excellent research work in clinical research in 2017

  • Award from the Swiss Society of Surgery SGC-SCC for promoting surgical research for research projects in applied basic and clinical research in 2017

  • Bruno Speck Award 2017: Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial

  • 3rd Poster Award Swiss Clinical Trial Organisation 2016: Nasal chondrocytes for articular cartilage repair: A Phase 1 “first-in-human” clinical trial

  • Award for the best presentation on Clinical Research Day at University Hospital Basel in 2014: Cartilage tissue engineering from nose to knee: first clinical application of a new concept

  • 1. AGA Research Award Innsbruck in 2014: Cartilage tissue engineering from nose to knee: first clinical application of a new concept

  • Dirk Schäfer research award from the Department of Surgery at University Hospital Basel for excellent research performance in experimental research in 2013

Fellowships 

  • AGA-Patellofemoral Fellowship, 2016 (Germany and Austria)

  • GOTS-Arthrex-ASIA Fellowship, 2018 (Japan and South Korea)

Clinical research in cartilage Regeneration

2015 – current
Principle Investigator, clinical coordinator and deputy sponsor of the European randomised Phase 2 multi-centre study funded by the European Union in the Horizon 2020 programme:  Bioengineered grafts for cartilage healing in patients (BIO-CHIP) (No.: 681103

2012 – 2019  
Co-principal investigator in a translational Phase 1 study funded by the Deutsche Arthrose-Hilfe eV aid association for osteoarthritis sufferers: Klinische Phase I Studie zur Regeneration von Gelenkknorpel mit gezüchtetem Nasenknorpel nach Knieverletzung (Clinical Phase I study on the regeneration of articular cartilage with cultured nasal cartilage after knee injury)

Publications (peer-reviewed)

  • Mumme M, Wixmerten A, Miot S, Barbero A, Kaempfen A, Saxer F, Gehmert S, Krieg A, Schaefer DJ, Jakob M, Martin I. Tissue engineering for paediatric patients. Swiss Med Wkly. 2019 Apr 5;149:w20032. doi: 10.4414/smw.2019.20032. eCollection 2019 Mar 25. IF: 1.928

  • Tachikart Y, Malaise O, Mumme M, Jorgensen C, Brondello JM. Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases. Biochem Pharmacol. 2019 Mar 13. pii: S0006-2952(19)30103-0. doi: 10.1016/j.bcp.2019.03.017. [Epub ahead of print] Review. IF: 4.235

  • Bartsch A, Lubberts B, Mumme M, Egloff C, Pagenstert G. Does patella alta lead to worse clinical outcome in patients who undergo isolated medial patellofemoral ligament reconstruction? A systematic review. Arch Orthop Trauma Surg. 2018 Jun 11. IF 1.967

  • Pelttari K, Mumme M, Barbero A, Martin I. Nasal chondrocytes as a neural crest-derived cell source for regenerative medicine. Curr Opin Biotechnol. 2017 May 25;47:1-6. IF: 9.294

  • Mumme M, Steinitz A, Nuss K, Feliciano S, Von Rechenberg B, Martin I, Barbero A, Pelttari K. Regenerative potential of tissue engineered nasal chondrocytes and their effect on joint homeostasis in goat articular cartilage defects. Tissue Eng Part A. 2016 Oct 11. IF: 3.485

  • Mumme M, Barbero A, Miot S, Wixmerten A, Feliciano S, Wolf F, Asnaghi AM, Baumhoer D,Bieri O, Kretzschmar M, Pagenstert G, Haug M, Schaefer  DJ, Martin I, Jakob M. Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial. Lancet 2016; 388: 1985–94 IF 47.831

  • Studer D, Cavalli E, Formica FA, Kuhn GA, Salzmann G, Mumme M, Steinwachs MR, Laurent-Applegate LA, Maniura-Weber K, Zenobi-Wong M.Human chondroprogenitors in alginate-collagen hybrid scaffolds produce stable cartilage in vivo. J Tissue Eng Regen Med. 2016 Jul 4. IF 3.989

  • Pelttari K, Pippenger B, Mumme M, Feliciano S, Scotti C, Mainil-Varlet P, Procino A, Von Rechenberg B, Jakob M, Cillo C, Barbero A, Martin I. Self-renewal and environmental plasticity of differentiated neural-crest derived adult human cells: relevance for articular cartilage repair. Sci Transl Med. 2014 Aug 27;6(251):251ra119. IF: 15.843

  • Steinwachs MR, Waibl B, Mumme M. Arthroscopic Treatment of Cartilage Lesions with Microfracture and BST-Cargel™® – A Technical Note. Arthrosc Tech. 2014 Jun 16;3(3):e399-402.

  • Steinwachs MR, Waibl B, Wopperer S, Mumme M. Matrix Associated Chondroplasty (MACH): A novel Platelet Rich Plasma and Concentrated Nucleated Bone Marrow Cells enhanced Cartilage Restoration Technique. Arthrosc Tech. 2014 Apr 21;3(2):e279-82.

  • Bocelli-Tyndall C, Trella E, Frachet A, Zajac P, Pfaff D, Geurts J, Heiler S, Barbero A, Mumme M, Resink TJ, Schaeren S, Spagnoli GC, Tyndall A. FGF2 induces RANKL gene expression as well as IL1β regulated MHC class II in human bone marrow-derived mesenchymal progenitor stromal cells. Ann Rheum Dis. 2015 Jan;74(1):260-6.  IF: 10.377

  • Krause M, Rupprecht M, Mumme M, Püschel K, Amling M, Barvencik F,. Bone Microarchitecture of the Talus Changes With Aging. Clin Orthop Relat Res. 2013 Nov;471(11):3663-71. IF: 2.882

  • Mumme M, Scotti C, Papadimitropoulos A, Todorov A, Hoffmann W, Bocelli-Tyndall C, Jakob M, Wendt D, Martin I, Barbero A. Interleukin-1β modulates endochondral ossification by human adult bone marrow stromal cells. Eur Cell Mater. 2012 Sep 24;24:224-36. IF: 4.558

  • Acharya C, Adesida A, Zajac P, Mumme M, Riesle J, Martin I, Barbero A. Enhanced chondrocyte proliferation and mesenchymal stromal cells chondrogenesis in coculture pellets mediate improved cartilage formation. J Cell Physiol. 2012 Jan;227(1):88-97. IF: 3.874

  • Beil FT, Barvencik F, Gebauer M, Mumme M, Beil B, Pogoda P, Rueger JM, Püschel K, Amling M. The Distal Radius, the Most Frequent Fracture Localization in Humans: A Histomorphometric Analysis of the Microarchitecture of 60 Human Distal Radii and Its Changes in Aging. J Trauma. 2011 Jan;70(1):154-8. IF: 2.478

  • Gebauer M*, Barvencik F*, Mumme M*, Beil FT, Vettorazzi E, Rueger JM, Pueschel K, Amling M. Microarchitecture of the radial head and its changes in aging. (*Co-First) Calcif Tissue Int. 2010 Jan;86(1):14-22. IF: 2.759

  • Barvencik F, Gebauer M, Beil FT, Vettorazzi E, Mumme M, Rupprecht M, Pogoda P, Wegscheider K, Rueger JM, Pueschel K, Amling M. Age- and sex-related changes of humeral head microarchitecture: histomorphometric analysis of 60 human specimens. J Orthop Res. 2010 Jan;28(1):18-26. IF: 2.976

  • Rupprecht M*, Pogoda P*, Mumme M*, Rueger JM, Püschel K, Amling M. Bone microarchitecture of the calcaneus and its changes in aging: A histomorphometric analysis of 60 human specimens. (*Co-First) J Orthop Res. 2006 Apr;24(4):664-74. IF: 2.784

Total: 119 impact points

Journal contributions          

  • Mumme M. Tissue Engineering zur Knorpelregeneration. LEADING OPINIONS Orthopädie & Rheumatologie 01/2017.

  • Mumme M, Martin I, Jakob M. Was sucht die Nase im Knie? VSAO Journal Nr. 1 Februar 2016

  • Mumme M, Martin I, Jakob M. Nose To Knee – Neue Wege in der Therapie von Knorpelschäden. Medical Sports Network 01/2015, 24-27.

  • Steinwachs MR, Guhlke-Steinwachs U, Mumme M. Diagnostik und operative Therapie von Gelenkknorpelschäden. Sportphysio 2013; 1: 10–15

  • Mumme M, Jakob M, Bless N. Zeitlich nahe Koinzidenz einer seltenen Verletzung des Bewegungsapparats beim gleichen Patienten – Fallbericht. Swiss medical forum. 2011.

  • Suhm N, Pretto M, Frank M, Conzelmann M, Tyndall A, Vogt T, Schulte F, Jakob M, Kressig R, Mumme M, Spirig R. Moderne Alterstraumatologie. Interdisziplinäre und interprofessionelle Behandlung im „Kompetenznetzwerk Altersfrakturen“. The Medical Journal 2009 Juni, Nr. 3, 16-20.

Book contributions

  • Steinwachs MR, Waibl B, Mumme M. Techniques in Cartilage Repair Surgery. Chapter 5- Matrix Enhanced Microfracture-Autologous Matrix-Induced Chondroneogenesis (AMICTM) Springer ESSKA 2014.

Presentations and talks       

  • Regenerate Mobility Innovation Workshop “Cartilage” 6.5.2019

  • AGA Akademie Kurs “Knorpelregeneration” Basel 13./14.7.2018

  • SwissOrthopedics Kongress “Assessing heterochronic parabiosis effects on osteo-articular loss of homeostasis in murine models” Montreux 7.6.2018

  • Update Ortho/Trauma/Hand “Regenerative Knorpelchirurgie Basel“ 26.4.2018

  • Nasenknorpel zur Regeneration von Gelenkknorpel- Was ist möglich? Knorpelsympsoium Bad Abbach 24.02.2018

  • Fortbildung Physiotherapie Kraftwerk – Regenerative Kniechirurgie Basel 05.02.2018

  • Vorlesung “Sportverletzung”  der Universität Basel im Fachbereich Medizin 20.11.2017

  • Rheumaliga Gelenkverletzungen Basel 19.10.2017

  • How a bio-derived collagen membrane supports the generation of articular cartilage from nasal cartilage cells. ICRS Summit Gothenburg 30.06.2017

  • Nasal chondrocytes for articular cartilage repair: update on clinical studies. TERMIS Davos 26.06.2017

  • Postoperatives Management und Rehabilitation nach Knorpeleingriffen. Anwendertreffen "Knorpelzelltransplantation (ACT) am Kniegelenk" Zürich 22.03.2017

  • Regenerative Chirurgie am Kniegelenk - Aktuelle Möglichkeiten und Grenzen. Update Ortho-Trauma-Hand Universitätsspital Basel 23.02.2017

  • Osteochondrale Làˆsion am Knie. GOTS Sommertreffen Brunnen 27.08.2016

  • From Nose to Knee. Pre-ESSKA Meeting: Cartilage Regeneration in the Knee Past – Present – Future Barcelona 03.05.2016

  • Pädiaterkurs des UKBB für Haus- und Kinderärzte, Modul Schulter/Ellenbogen. Basel, 12.11.2015

  • Therapy of cartilage defects. Swiss Society of Muskuloskeletal Radiology Basel 31.10.2015

  • Therapy of patellar dislocation and trochlea dysplasia. Swiss Society of Muskuloskeletal Radiology Basel 31.10.2015

  • Cartilage tissue engineering from nose to knee. DKOU (Deutsche Gesellschaft für Orthopädie und Unfallchirurgie), Berlin 23.10.2015

  • Tissue Engineering – Möglichkeiten und Grenzen der Regenerativen Medizin. Nacht des Wissens der Universität Basel, Basel 18.09.2015

  • Instructional course Cartilagy therapy. Meet the expert. Cartilage tissue engineering from nose to knee. AGA Gesellschaft für Arthroskopie und Gelenkchirurgie, Dresden 18.09.2015

  • Cartilage tissue engineering from nose to knee: 12 Months Results of a Phase 1 Clinical Trial. EFORT Prag 2015, SGOT Basel 2015.

  • Cartilage tissue engineering from nose to knee: 12 Months Results of a Phase 1 Clinical Trial. SGOT (Schweizerische Gesellschaft für Orthopädie und Traumatologie), Basel 25.06.2015

  • Cartilage tissue engineering from nose to knee. 12 Months Results of a Phase 1 Clinical Trial. EFORT (European Federation of National Associations of Orthopaedics and Traumatology), Prag 29.05.2015

  • Knieschmerzen beim sportlichen Kind. Infobombe, Hirslandenklinik Muttenz/Basel 2015

  • Gelenkverletzung: Hilfe durch körpereigene Zellen. Basel Stem Cell Network 17.04.2015.

  • Cartilage tissue engineering from nose to knee: first clinical application of a new concept. AGA Kongress Innsbruck 2014, AO Cartilage& Disc Davos 2014, EORS Nantes 2014.

  • Tissue engineered nasal cartilage for the regeneration of post traumatic cartilage injuries in the knee – early results of a Phase 1 Clinical Trial. ESSKA congress 2014 Amsterdam.

  • Tissue engineered nasal cartilage for the regeneration of articular cartilage in goats. CORS 2013 Venedig, Schweizer Kongress für Chirurgie 2012 Davos, Research Day of the Department of Surgery University Hospital Basel 2012, AGA Kongress 2012 Zürich.

  • IL-1β modulates in vitro remodeling and in vivo bone formation by endochondral primed human bone marrow mesenchymal stromal cells. Schweizer Kongress für Chirurgie 2012 Davos.

  • IL-1β enhances chondrogenic and osteogenic differentiation and endochondral priming of human mesenchymal progenitor/stem cells. Orthopaedic Research Society 2012 San Francisco.

  • Orthobiologic solutions for the hip – any evidence? 7th Instructional Course in Biomechanics - The Hip 2012 Pontresina.

  • Pathophysiology of cartilage defects. Schweizer Kongress für Orthopädie und Traumatologie 2011 Lausanne.

  • Regulation of osteogenic and chondrogenic differentiation of mesenchymal progenitor/stem cells by IL-1β and oxygen. TERMIS EU 2011 Annual meeting Granada and AOER 2011 Davos.

  • Cannulated hip screws for the prophylactical fixation of femoral neck fractures Garden type I or II. An adequate treatment for patients 65+? Schweizer Kongress für Orthopädie und Traumatologie 2010 St. Gallen, Kongress der deutschen Gesellschaft für Unfallchirurgie 2010 Berlin, Schweizer Kongress für Chirurgie 2011 Genf.

Funds from secondary sources  

  • Smith&Nephew: Marcus Mumme, Geert Pagenstert. Evaluation of BST Cargel® for the arthroscopic application of nasal chondrocytes for cartilage regeneration. CHF 25,000  

  • Horizon 2020: Prof. Dr. Ivan Martin. BIOengineered grafts for Cartilage Healing In Patients (BIO-CHIP). €5.1 million (Co-author und key personnel in the application, key role in the application, development of the study design)

  • Deutsche Arthrosehilfe (German aid association for osteoarthritis sufferers): Dr. med. Marcus Mumme, Prof. Dr. Ivan Martin, Prof. Dr. med. Marcel Jakob, PD Dr. med. Markus Arnold. Klinische Phase I Studie zur Regeneration von Gelenkknorpel mit gezüchtetem Nasenknorpel nach Knieverletzung (Clinical Phase I study on the regeneration of articular cartilage with cultured nasal cartilage after knee injury) €157,000 Project code: P245-A546-Martin-EP1-mumm1-knie-op-III—2011-15

  • Deutsche Arthrosehilfe (German aid association for osteoarthritis sufferers): Dr. med. Marcus Mumme, Anke Wixmerten, Prof. Dr. Ivan Martin, Prof. Dr. med. Marcel Jakob. Erweiterte klinische Phase I Studie zur Regeneration von Gelenkknorpel mit gezüchtetem Nasenknorpel nach Knieverletzung (Extended clinical Phase I study on the regeneration of articular cartilage with cultured nasal cartilage after knee injury) €10,000 Project code: P305-A546-Mumme-EP2-wixm1-knie-op-III-10k-2014-15

Activities as a reviewer

  • Swiss National Science Foundation

  • ETH Zurich Research Commission

  • Journal European Cells & Materials

  • BMC Musculoskeletal Disorders

  • Journal of Children’s Orthopaedics

  • Journal Regenerative Medicine Research

  • Journal Cartilage

  • Archives of Orthopaedic and Traumatologic Surgery

Teaching

  • Lecture: Sportverletzung bei Erwachsenen und Kindern (Sports injuries in adults and children) at the Faculty of Medicine, University of Basel

  • Lectures and seminars: Prävention und Gesundheitsförderung (Prevention and health promotion) at the Faculty of Medicine, University of Basel

  • Study courses at the Faculty of Medicine, University of Basel

  • Paediatric courses (paediatric orthopaedic training at the University Children’s Hospital of Basel)

Memberships and working groups           

  • Member of the AGA committee on knee cartilage and meniscus

  • Member of the AGA committee on regeneration and translation

  • Foederatio Medicorum Helveticorum (FMH)

  • Orthopaedic and trauma sports medicine association (GOTS)

  • Society for Arthroscopy and Joint Surgery (AGA)

  • South Baden Medical Association, Baden-Württemberg, German Medical Association